Familial Breast Ovarian Cancer Panel
Breast/ovarian cancer is among the most common types of cancer in the world. It’s known that 5-10% of breast cancer cases are familial. Many genes have been identified that are involved in hereditary predisposition to breast and/or ovarian cancer. The most important of these genes are BRCA1 and BRCA2 genes responsible for HBOC (Hereditary Breast and Ovarian Cancer) syndrome. Mutations in BRCA1 and BRCA 2 genes are the most important causes of hereditary breast and ovarian cancers. Approximately 46-87% of these cancers are caused by mutations in these two genes.
What genetic tests are associated with breast and ovarian cancer?
Who should have a genetic test?
Why do we recommend breast and ovarian cancer genetic tests (brca1 / 2)? What is its benefit for the patient?
Genetic counseling in breast and ovarian cancer
BRCA1 and BRCA2 are inherited in an autosomal dominant manner. The vast majority of individuals with the BRCA1 or BRCA2 pathogenic variant inherited it from one parent. While many people have a family history of cancer, the majority of breast and ovarian cancers are not actually due to hereditary causes. Cancers that occur due to genetic differences in the genetic makeup of the parents, called ‘mutations’, that can be passed on to later generations, namely their children, are called ‘hereditary cancers’. Genetic counseling is recommended for inherited cancer syndromes before and after genetic testing. Detection of hereditary gene mutations is possible by analyzing the tissue and blood samples taken from the person with genetic techniques. It is recommended that these test results be obtained with genetic counseling.